Endocrine Abstracts

IntroductionA pheochromocytoma is a tumor arising from adrenomedullary chromaffin cells that commonly produces one or more catecholamines. About 80 to 85% of chromaffin-cell tumors are pheochromocytomas. It is recommended that initial biochemical testing should include measurements of plasma free metanephrines or urinary fractionated metanephrines. 123I-metaiodobenzylguanidine (MIBG) scintigraphy is a functional imaging modality, in patients w...

Introduction: Somatostatin analogues (SA) are the first-line treatment for Acromegaly in patients whose surgery failed to achieve cure or it was contraindicated. The main reported adverse events of SA are mild and transient, and include nausea, abdominal cramps, diarrhea and flatulence. Other side effects are of rare occurrence.Case report: The authors describe a case of a 44-year-old previously asymptomatic male patient with a growth hormone-secreting p...

Introduction: Langerhans Cell Histiocytosis (HCL) is a rare granulomatous disease, unknown etiology, with a wide clinical spectrum. The pituitary is affected in 25% of cases, with diabetes insipidus being the earliest and most frequent feature. Although it is more common in pediatric age, it can also be developed by adults.Clinical case: A 39-year-old, caucasian, woman presents with polydipsia with 5L/day of water and an appetite for cold drinks, polyuri...

IntroductionAlthough most patients with COVID-19 have mild symptoms, some develop severe manifestations of the disease, leading to hospitalization and death. Previous studies reported that calcium played a central role in viral infections and replicative mechanisms of SARS-CoV. Hypocalcemia is a common finding among these patients. The aim of this study was to investigate the prevalence of hypocalcemia in a population of COVID-19 patients and to evaluate...

IntroductionSome studies have shown low-density lipoprotein cholesterol (LDL) and triglyceride (TG) levels were significantly lower in high-Killip (III + IV) patients compared with low-Killip (I + II) patients and in those who died after acute myocardial infarction (AMI) compared with those who survived beyond 30 days, which they called lipid paradox. Elevated levels of LDL and triglycerides are important risk factors for cardiovascular disease, ...

BackgroundType 2 Diabetes Mellitus (T2DM) and Heart Failure (HF) are two directly related diseases associated with considerable morbimortality. The prevalence of HF in T2DM populations is up to 20%, 4 times higher than the general population. Additionally, health-related quality of life, hospitalizations for HF (HHF) and mortality risk are more common when both are present. Hence, HHF risk assessment in T2DM patients may lead to prompt preventive interve...

Objectives: To evaluate the relationship between free T3 (FT3) levels with symptoms suggestive of thyroid dysfunction, and quality of life (QoL) outcomes, in patients with compensated primary hypothyroidism (PH).Methods: Cross-sectional study encompassing Portuguese levothyroxine(LT4)-treated patients for PH who presented Thyroid-stimulating hormone (TSH) and free T4 (FT4) within the normal range. Pregnant women, patients with central hypothyroidism and/...

Introduction: Diabetic ketoacidosis (DKA) is characterized by the triad – ketonemia, metabolic acidosis and hyperglycemia. It is typically associated with type 1 Diabetes Mellitus (T1D) and the most common culprits are infections and poor therapeutic compliance.Clinical Case DescriptionThe present case deals with a 25–year–old female patient, with T1D diagnosed in 2008, without microvascular or macrovascular compl...

Introduction: Grave´s disease (GD) is the most prevalent cause of hyperthyroidism, leading to inflammation of the thyroid gland and sometimes to an enlargement of the nearest lymph nodes caused by that same inflammatory process. Peripheral lymphadenopathy of doubtful cause presents a diagnostic dilemma. There are many potential causes: biopsy is sometimes the best way to reach a definitive diagnosis. Tuberculous adenitis is usually regional and mainly affects nodes of the...

IntroductionFollicular thyroid carcinoma (FTC) has metastasis in 10-15%; papillary thyroid carcinoma (PTC) rarely metastasizes. Bone metastasis are rare and can cause pain, fractures and spinal cord compression.Case-172 year-old male referred to the hospital with lower back pain. Imaging examination revealed lytic lumbar lesions. Thoracic-abdominal-pelvic-CT showed trachea compression by a multinodular right ...